Table 2.
Compounds | CC50 | Con A IC50 | SI | LPS IC50 | SI |
---|---|---|---|---|---|
(μM) | (μM) | (μM) | |||
SOMCL-17-016 | 9.44 ± 0.25 | 0.59 ± 0.17 | 17.44 ± 4.5 | 0.02 ± 0.01 | 601.88 ± 202.29 |
Ibrutinib | 1.91 ± 0.16 | 0.46 ± 0.22 | 5.19 ± 2.16 | 0.07 ± 0.02 | 28.20 ± 5.45 |
Acalabrutinib | 30.87 ± 2.17 | 13.87 ± 3.42 | 2.41 ± 0.75 | 0.66 ± 0.11 | 47.81 ± 4.56 |
CC50, The cytotoxic concentration of the compound that reduces cell viability by 50%; IC50, The inhibitory concentration of the compound that reduces cell proliferation by 50%; Selective Index (SI) = CC50/IC50.