Table 1.

Dose criteria of RTOG 0933 protocol and additional constraints used in the current study.

	Per protocol	Variation acceptable	Deviation unacceptable
RTOG 0933 protocol
Whole-brain PTV	D2% ≤ 37.5 Gy	D2% ≤ 40 Gy	D2% > 40 Gy
	D98% ≥ 25 Gy	D98% < 25 Gy	V30 Gy ≤ 90%
Hippocampus	D100% ≤ 9 Gy	D100% ≤ 10 Gy	D100% > 10 Gy
	Dmax ≤ 16 Gy	Dmax ≤ 17 Gy	Dmax > 17 Gy
Optic nerve and chiasm	Dmax ≤ 37.5 Gy	Dmax ≤ 37.5 Gy	Dmax > 37.5 Gy
Additional constraints
Inner ear	Dmean ≤ 15 Gy	Dmean ≤ 16 Gy	Dmean > 16 Gy
Lens	Dmax ≤ 9 Gy	Dmax ≤ 10 Gy	Dmax > 10 Gy
Eye	Dmean ≤ 11 Gy	Dmean ≤ 12 Gy	Dmean > 12 Gy