The levels of immunoglobins and cytokines in serum were analyzed by a protein chip array. a Levels of IgG1, IgG2, IgG3, and IgG4 in RA patients compared with HCs. b Levels of IgA and IgM in RA patients compared with HCs. c Levels of IgE and IgD in RA patients compared with HCs. d Levels of IL-1α, IL-1β, IL-6, and IL-8 in RA patients compared with HCs. e Levels of TNF-α, IFN-γ, and MCP-1 in RA patients compared with HCs. f Levels of IL-4, IL-10, and IL-13 in RA compared with HCs. Each sample was run in quadruplicate. The number of samples was 50. *P < 0.05, **P < 0.01 vs. HCs. HCs healthy controls.