Skip to main content
. 2021 Jan 25;42(10):1587–1597. doi: 10.1038/s41401-020-00585-1

Fig. 5. Zonisamide alleviated ER stress in the rats hearts and NRCMs.

Fig. 5

Rats in the sham (vehicle), AAC (vehicle), and A+Z 14 groups were treated with vehicle or zonisamide for 6 weeks. NRCMs were incubated with zonisamide and Ang II for 24 h. a, b Protein levels of phosphorylation of PERK (p-PERK), PERK, ATF4, ATF6, XBP1, GRP78, and GRP94 in rats hearts were measured by Western blotting and densitometric quantification after normalization to the GAPDH level (n = 7). c, d Protein levels of phosphorylation of PERK (p-PERK), PERK, ATF4, ATF6, XBP1, GRP78, and GRP94 in NRCMs were measured by Western blotting and densitometric quantification after normalization to the GAPDH level (n = 7). Data were analyzed by one-way ANOVA. Values are presented as the mean ± SEM. For b, *P < 0.05, **P < 0.01 vs. sham; #P < 0.05 vs. AAC. For d, *P < 0.05 vs. Con; #P < 0.05, ##P < 0.01 vs. Ang II.