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. 2021 Sep 24;12:5623. doi: 10.1038/s41467-021-25921-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Expression of CSC factors by PDAC cells (12560) cultured in PA-ECM compared to 2D monolayers (mean ± SD; n = 3 biological replicates). b Percentage of CD133 + /CXCR4 + PDAC cells in PDX and ex vivo PDAC models as assayed by flow cytometry in three matched experiments (mean ± SD). c Number of spheres by size range formed by PDAC cells (12560) derived from PA-ECM cultures, primary spheres, organoids and 2D monolayers (mean ± SD; n = 3 biological replicates). d Engraftment rate of PA-ECM and organoid PDAC cultures (12560) implanted in nude mice (three mice with two tumours per condition). e Volume of tumours grown in nude mice from implanted PA-ECM and organoid cultures carrying increasing numbers of PDAC cells (12560) (three mice with two tumours per condition). Shaded areas denote standard deviation around mean. f Representative histology images of PDAC tissues derived from patient 12560, including primary tumour, patient-derived xenografts and tumours grown in nude mice from implanted PA-ECM and organoid cultures. Scale bars: 100 µm.