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. 2021 Sep 24;12:5639. doi: 10.1038/s41467-021-25296-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The ROC of the RNN model for classifying the slides of groups E and F (n = 1,170). b Comparison of the RNN model and three cytopathologists at the slide level (n = 121). The most confusing 121 slides of the 1,170 slides were classified by the RNN model and the three cytopathologists. Each green triangle refers to 1-specificity and sensitivity of a cytopathologist’s result. c Comparison of the HR model and the three cytopathologists at the tile level. Randomly selected 1018 positive test tiles and 3,047 negative test tiles with a size of 256 × 256 (0.243 μm/pixel) from groups E and F (n = 4,065 tiles) were simultaneously classified by the HR model and three cytopathologists. d The average true positive numbers of the recommended top 10 and top 20 lesion cells on positive slides in groups E and F (n = 447), evaluated by three cytopathologists separately. The boxes indicate the upper and lower quartile values, the whiskers indicate the 95% and 5% quantile values, the middle bold solid line and dotted lines indicate the mean and median values, and the scatter dots indicates outliers.