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. 2021 Sep 24;12(10):871. doi: 10.1038/s41419-021-04159-9

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© The Author(s) 2021, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Ear thickness (μm) of mice was measured 24 h after MC903 final application on day 7 by using a vernier caliper from wild-type (WT) or Nlrp3^-/- mice. Ear swelling was obtained by analysis of the thickness difference between the left and right ears of each mouse. B Ear weight (mg) of mice was assessed 24 h after MC903 final application on day 7 in the same volume of ear tissue obtained by a tissue punch. C Ear histological changes were evaluated with H&E staining and images were observed with optical microscopy (magnification: ×100, scale bar: 100 μm). D, qRT-PCR analysis of Il33 mRNA expression in ear homogenates from WT or Nlrp3^-/- mice. E Secretion level of IL-33 in ear homogenates from WT or Nlrp3^-/- mice was evaluated by ELISA. F–G, Secretion level of TSLP and IL-1β was evaluated by ELISA in ear homogenates from WT or Nlrp3^-/- mice. Statistical comparisons were performed using One-way ANOVA analysis of variance with Dunnett’s test in multiple comparison (all data are represented as the mean ± SD of two independent experiments, n = 6, *P < 0.05; **P < 0.01 vs. Control or WT-AD).