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. 2021 Jan 18;42(10):1575–1586. doi: 10.1038/s41401-020-00587-z

Fig. 5. 6-Gingerol mitigated PE-induced cardiomyocyte hypertrophy in vitro but did not protect NRCMs expressing constitutively active p38.

Fig. 5

a Cell surface area was determined by α-actinin immunofluorescence staining and the quantitative analysis of NRCMs (n = 6). b Representative immunofluorescence staining of p-p38 and the percentage of p-p38-positive nuclei in NRCMs (n = 6). c Representative Western blots showing total and phosphorylated p38 and the statistical analysis of the ratios of phosphorylated-to-total p38 in NRCMs (n = 6). d The effect of 6G on p38 phosphorylation in NRCMs infected with Ad-MKK6 (n = 6). e, f The effect of 6G on PE-induced cardiomyocyte hypertrophy in NRCMs with sustained p38 activation (n = 6). 6G 6-Gingerol. *P < 0.05 vs. the corresponding control group. #P < 0.05 vs. the PE + vehicle group. NS no statistical significance.