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. 2021 Jan 18;42(10):1575–1586. doi: 10.1038/s41401-020-00587-z

Fig. 6. 6-Gingerol blocked TGF-β-induced cardiac fibroblast activation and differentiation in a p38-dependent manner in vitro.

Fig. 6

a Representative immunofluorescence staining of α-SMA and statistical analysis of the α-SMA intensity in cardiac fibroblasts (CFs). b, c Representative immunofluorescence staining of phosphorylated Smad3 and p38 and the statistical analysis of the positive nuclei percentage (n = 6). d Representative Western blots showing p-Smad3, t-Smad3, and α-SMA in CFs and the statistical analysis (n = 6). e, f The effects of 6G on α-SMA intensity and Smad3 activation induced by TGF-β in CFs infected with Ad-MKK6 (n = 6). 6G 6-Gingerol. *P < 0.05 vs. the corresponding control group. #P < 0.05 vs. the TGF-β + vehicle group. NS no statistical significance.