Figure 5.

Cases of Radiation-Induced Cardiovascular Disease

(A) Severe coronary artery disease on coronary computed tomography angiography. A 57-year-old woman underwent adjuvant chemotherapy and radiation therapy for left-sided breast cancer 14 years ago with normal coronary arteries on cardiac catheterization 7 years ago. She developed electrocardiography changes on ribociclib but was asymptomatic. A computed tomography angiogram showed >70% proximal left anterior descending artery (LAD) disease, and she was started on preventive therapy. A few months later, she began having angina and underwent percutaneous coronary intervention. (B) Iliac vein stenosis 1 year after pelvic radiation. A 70-year-old with prostate cancer developed iliac vein stenosis requiring stenting 1 year after radiation therapy. He notably also had baseline atherosclerotic disease manifesting as an abdominal aortic aneurysm and aorto-iliac calcifications before his radiation therapy.