Fig. 4.

Doxycycline restores circadian motor activity in Tg(FFI-26) mice. Bars indicate the mean ± SEM of activation density metric (average activations over the 12 electrodes of the board and within the selected time interval, expressed as percentage) of 9 vehicle-treated non-Tg, 8 doxy-treated non-Tg, 8 vehicle-treated Tg(FFI-26) and 9 doxy-treated Tg(FFI-26) mice, during the whole period of monitoring throughout the DVC® system and aggregated in 3-h bins. A generalized linear mixed-effects model with a heterogeneous first-order autoregressive correlation structure and lognormally distributed residuals was used. In case of interaction effects, additional Bonferroni's post-hoc tests were done. The key post-hoc comparisons within each time block are indicated in gray (Tg(FFI) vehicle vs. non-Tg vehicle) or magenta (Tg(FFI) doxy vs. non-Tg doxy); *P < 0.05, ns, non-significant. All multiple comparisons are reported in Supplementary Table 1. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)