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Image of FOLFIRI-treated HCT 116 spheroids.A, localization of irinotecan and folinic acid within 24-h treatment. B, a metabolite of folinic acid was detected in the proliferating layer of the spheroids. Reprinted with permission from Ref. (115). Copyright (2018) American Chemical Society. FOLFIRI, FOL: folinic acid/leucovorin; F: 5-fluorouracil (5-FU); and IRI: irinotecan.
