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. 2021 Aug 28;297(4):101139. doi: 10.1016/j.jbc.2021.101139

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Mapping of endogenous metabolites in MCF-7 breast cancer spheroids by MALDI-MSI. Elemental formula of the metabolites assigned can be mapped onto the hexosamine biosynthetic pathway (HBP). N-acetyl neuraminic acid (sialic acid) is formed by the end product of the HBP. Adapted with permission from Ref. (18). Copyright (2019) American Chemical Society. CMP, cytidine monophosphate; CMP-NeuAc, cytidine monophosphate N-acetylneuraminic acid; GlcNAc-1-P, N-acetyl glucosamine-1-phosphate; ManNAc-6-P, N-acetylmannosamine-6-phosphate; MSI, MS imaging; NeuNAc, N-acetylneuraminic acid; Neu9NAc-9-P, N-acetylneuraminic acid-9-phosphate; UDP, uridine diphosphate; UDP-GlcNAc, uridine diphosphate-N-acetyl glucosamine; UMP, uridine monophosphate; UTP, uridine triphosphate.