Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 28;297(4):101139. doi: 10.1016/j.jbc.2021.101139

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Analysis of BKM120 and dabrafenib penetration by MALDI–MSI. BBB organoids were incubated with 10 μM of either drug for 24 h. MALDI-MSI ion images show successful detection of BKM120 accumulation within the organoids (green; top row; m/z = 411.1751 ± 0.001). Dabrafenib was not detected within the organoids (bottom row; m/z = 520.1083 ± 0.001). Dashed lines on the scanned images delineate the positions of the BBB sphere tissue sections. This figure is adapted from Ref. (116) under a Creative Commons Attribution 4.0 license (https://creativecommons.org/licenses/by/4.0/legalcode). BBB, blood–brain barrier; MSI, MS imaging.