Fig. 1.

(A): a; Endothelial targeted antioxidant NPs formation scheme by controlled precipitation, b; Binding of Ab-PAC to cultured endothelial cells. ¹²⁵I- labeled PACs incubated with cells at 37 °C, rinsed, lysed and measured for radioactivity, c; Tissue distribution of intravenous injected PACs into mice after 30 min circulation time. Protection by endothelial-targeted catalase PACs from oxidative stress in vitro (d) and in vivo based on brochoalveolar lavage (BAL) protein (e-f) [105]. (B): a; transmission electron micrograph of DendGDP NPs, b; Release of Dox from the NPs in the absence or presence of cathepsin (50 U), c; near-infrared fluorescence images for CT26-bearing male nude BALB/c mice. Dox itself or Dox-conjugated dendrimer NPs (5 mg/kg) were injected into the tail vein of each mouse. The major organs were removed from each mouse 48 h after injection [108].