Table 1.
Patient and tumor characteristics.
| Variable | No. (%) |
|---|---|
| No. of patients | 296 (100.0%) |
| Age, years | |
| Median (IQR) | 57 (46, 68.5) |
| Age, years | |
| ≤50 | 112 (37.8%) |
| >50 | 184 (62.2%) |
| Neoadjuvant chemotherapy | |
| No | 170 (57.4%) |
| Yes | 125 (42.2%) |
| Unknown | 1 (0.3%) |
| Nodal pCR rate after neoadjuvant therapy | 71 (24.0%) |
| Type of breast surgery | |
| Breast conserving | 179 (60.5%) |
| Mastectomy + - reconstruction | 116 (39.2) |
| Nonea | 1 (0.3%) |
| Tumor size at initial diagnosis, mm | |
| Median (IQR) | 28 (20, 40) |
| Clinical T stage at initial diagnosis | |
| T0 | 1 (0.3%) |
| T1 | 67 (22.6%) |
| T2 | 189 (63.9%) |
| T3 | 28 (9.5%) |
| T4 | 9 (3.0%) |
| Tis (DCIS) | 1 (0.3%) |
| Tx | 1 (0.3%) |
| Clinical N stage at initial diagnosis | |
| N1 by palpation | 137 (46.3%) |
| N1 by imaging | 136 (45.9%) |
| N2/3 | 23 (7.8%) |
| Postoperative N stage | |
| pN0 | 5 (1.7%) |
| pN1mi | 0 (0.0%) |
| pN1 | 102 (34.5%) |
| pN2 | 39 (13.2%) |
| pN3 | 20 (6.8%) |
| ypN0 | 71 (24.0%) |
| ypN0(ITC) | 2 (0.7%) |
| ypN1 | 46 (15.5%) |
| ypN2 | 9 (3.0%) |
| ypN3 | 2 (0.7%) |
| Histology | |
| Invasive ductal | 223 (75.3%) |
| Lobular | 27 (9.1%) |
| Other | 46 (15.5%) |
| Receptor status at initial diagnosis | |
| HR+/Her2- | 187 (63.2%) |
| HR+/Her2+ | 42 (14.2%) |
| HR-/Her2+ | 16 (5.4%) |
| HR-/Her2- | 35 (11.8%) |
| Missing/unknown | 16 (5.4%) |
| LVI | |
| Yes | 147 (49.7%) |
| No | 138 (46.6%) |
| Missing/unknown | 11 (3.7%) |
| Modified Bloom-Richardson score | |
| I | 11 (3.7%) |
| II | 162 (54.7%) |
| III | 116 (39.2%) |
| Missing/unknown | 7 (2.4%) |
Abbreviations: IQR, interquartile range; pCR, pathologic complete response; NST, no special type; LVI, lymphovascular invasion.
a
Primary tumor was inoperable and surgical treatment consisted exclusively of axillary surgery.