Fig. 3.

Topical application of arctigenin ameliorated experimental murine psoriatic skin lesions. (A) BALB/c mice were acquired with IMQ cream and treated daily with 5% arctigenin cream and body weight changes (exhibited as the percentage of the initial weight) were monitored daily. (B) Skin PASI total scores. (C) Skin inflammatory scores, including scales, thickness, and erythema. (D) The representative manifestations of the back skins. (E) Epidermal thicknesses, acquired from H&E staining. (F) The typical H&E staining pictures of tissue slices (100 × magnification). (G) Spleen index, referring to spleen weight (mg)/body weight (g). (H) The representative immunohistochemistry staining of Ki-67 in skin slices (200 × magnification). (I) Serum cytokines, quantified by Luminex assay. All data were shown as means ± SEM; n = 7 mice per group. *p < 0.05, **p < 0.01, and ***p < 0.001, compared with IMQ-treated mice.