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. 2021 Mar 4;33:241–251. doi: 10.1016/j.jare.2021.02.006

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© 2021 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Quantitative proteomic analysis of arctigenin-intervened psoriatic skin lesions. (A) Flow chart of the TMT-labeled quantitative proteomic study on murine skin samples. (B) The principle component analysis (PCA) of three groups. (C) Venn diagram indicated the shared and uniquely identified proteins in three groups. (D) Number of differential expressed proteins of different groups and the protein which meet the requirements (Foldchange = 1.2 and p-value < 0.05) is listed. (E) Volcano plot of differential expressed proteins between vehicle and arctigenin-treated vehicle mice. (F) Cluster analysis of differential protein expression level in vehicle and arctigenin-treated vehicle mice. (G) Correlation analysis of protein expression (Top50 significantly different proteins between vehicle mice (IMQ-treated only) and arctigenin-treated vehicle mice).