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. 2021 Mar 4;33:241–251. doi: 10.1016/j.jare.2021.02.006

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© 2021 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Arctigenin suppressed the PDE4-mediated inflammation in IMQ-induced psoriasis. (A) The enzymatic activity of cAMP-specific PDE in skins. (B) The cAMP levels in skins. (C) The enzymatic activity of cAMP-specific PDE4 in RAW264.7 cells and LPS-stimulated RAW264.7 cells (D). (E) Western blotting assay of phosphorylation of CREB in skins. (F) The mRNA level of cytokines in the inflamed tissues. All data were shown as means ± SEM; n = 7 mice per group. *p < 0.05, **p < 0.01, and ***p < 0.001, compared with IMQ-treated mice.