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. 2021 Sep 24;4(9):e2125584. doi: 10.1001/jamanetworkopen.2021.25584

Figure 2. Hypometabolism in GRN Variation Carriers Relative to Age-Matched Controls.

Figure 2.

Regions of fluorodeoxyglucose (FDG) hypometabolism in all GRN variation carriers (A) and in symptomatic GRN variation carriers (B). The depicted results meet a primary voxel-level threshold of uncorrected P < .001 and a cluster-level threshold of familywise error P < .05. Voxels meeting a more stringent threshold of familywise error P < .05 are detailed in eTable 3 in Supplement 2. No voxels met this threshold in prodromal variation carriers (n = 8). SUVR indicates standardized uptake value ratio.