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. 2021 Sep 24;4(9):e2125584. doi: 10.1001/jamanetworkopen.2021.25584

Figure 3. Frontal Fluorodeoxyglucose (FDG) Hypometabolism vs Clinical Severity and Cerebrospinal Fluid (CSF) Biomarkers in GRN Gene Variation Carriers.

Figure 3.

In voxelwise analyses, low frontal FDG–standardized uptake value ratio (SUVR) was associated with higher Clinical Dementia Rating (CDR) plus National Alzheimer’s Coordinating Center (NACC) frontotemporal lobar degeneration (FTLD) sum of boxes score (A) and higher CSF neurofilament light chain (NfL) (C). Low bifrontal FDG-SUVR on a bifrontal composite region of interest was also associated with high CDR plus NACC FTLD sum of boxes score (B), and CSF NfL (D) but not plasma progranulin (E) or CSF progranulin (F). The shaded areas in panels B, D, E, and F represent the 95% CIs.