. 2021 Jul 8;17(2):440–449. doi: 10.4103/1673-5374.317986

Table 4.

Quantitative enrichment analysis of differentially expressed genes of OB compared with OM in KEGG signaling pathway

Name	KEGG map	P-value	q-value	Up_Gene*	Down_Gene*
Cytokine-cytokine receptor interaction	map04060	1.14E-09	3.94E-07	Cd40\|K03160; Tnfsf15\|K05478; Cxcl2\|K05505; Tnfrsf19\|K05155; Tnfsf18\|K05479	Ccl3\|K05408; Ccl6\|K05510; Ccl4\|K12964; Ccl9\|K22671; Ccl11\|K16597; Tgfb3\|K13377; Bmp4\|K04662; Tnfrsf25\|K05160; Il18rap\|K05174; Il1rl1\|K05171; Tnfrsf11a\|K05147; Il1rn\|K05481; Il1b\|K04519; Tnfrsf9\|K05146; Cxcl9\|K05416; Il13ra2\|K05077; Ccl17\|K21083; Gdf7\|K20013; Il31ra\|K22630; Gdf6\|K20012; Csf2rb\|K04738; Gm16008\|K05154
Cell adhesion molecules	map04514	1.53E-07	2.64E-05	Cadm3\|K06780; Cd40\|K03160; Nrcam\|K06756; Nfasc\|K06757; Itga6\|K06485; L1cam\|K06550; Cadm1\|K06781; Nrxn2\|K07377; Cntnap2\|K07380; Ntng1\|K07522; Nlgn1\|K07378	Itgb2\|K06464; Cldn1\|K06087; Nrxn1\|K07377; Ptprc\|K06478; Selp\|K06496; Siglec1\|K06548
Axon guidance	map04360	1.75E-05	0.002023	Sema4f\|K06521; Sema6b\|K06842; Sema3g\|K06840; Sema4c\|K06521; Nfatc2\|K17332; Epha5\|K05106; Plxna4\|K06820; Plxnb3\|K06821; L1cam\|K06550; Wnt4\|K00408; Sema7a\|K06529; Ntng1\|K07522	Shh\|K11988; Rac2\|K07860; Sema3f\|K06840; Gdf7\|K20013; Plxnc1\|K06572
Malaria	map05144	0.000201	0.017389	Cd40\|K03160	Itgb2\|K06464; Cd36\|K06259; Tgfb3\|K13377; Selp\|K06496; Il1b\|K04519; Hgf\|K05460
Rhoptry-associated protein 1 signaling pathway	map04015	0.000385	0.022218	Pdgfb\|K17386; Kit\|K05091; Fyb\|K17698; Adcy5\|K08045; Arap3\|K12490; Fgf5\|K04358; Gm8399\|K05692; Cnr1\|K04277; Fgf18\|K04358	Itgb2\|K06464; Rapgef3\|K08014; Hgf\|K05460; Pdgfra\|K04363; Vegfd\|K05449; Rac2\|K07860; Rapgef5\|K08019; Fpr1\|K04172

* Gene name|protein accession number. KEGG: Kyoto Encyclopedia of Genes and Genomes analysis; OB: olfactory ensheathing cells derived from the olfactory bulb; OM: olfactory ensheathing cells derived from the olfactory mucosa.