Table 2.
The topographical disruptions of GFAP and Iba1 mRNA and protein expression levels seen in response to spinal cord injury after 24 hours
| Brain Region | GFAP mRNA | GFAP protein | Iba1 mRNA | Iba1 protein |
|---|---|---|---|---|
| Amygdala | ↑ | ↑ | No change | No change |
| Periaqueductal gray | No change | No change | No change | No change |
| Prefrontal cortex | No change | No change | No change | No change |
| Hypothalamus | ↑ | ↑ | No change | No change |
| Thalamus | ↓↓ | ↓↓ | No change | No change |
| Dorsal hippocampus | ↓ | ↓↓ | ↓ | ↓↓ |
| Ventral hippocampus | No change | No change | ↓ | ↓ |
Arrows indicate the direction (upregulation or downregulation) and statistical significance (one arrow indicates P ≤ 0.05, two arrows if P ≤ 0.01, vs. sham) of the observed changes. GFAP: Glial fibrillary acidic protein; Iba1: Ionized calcium binding adaptor molecule 1.