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. 2021 Jul 8;17(2):433–439. doi: 10.4103/1673-5374.314319

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MiR-29b antagomir inhibits apoptosis in cerebral ischemia model mice.

(A) Caspase3 immunopositivity (red, stained by fluorescein) in mouse brain tissue (original magnification, ×200). The immunopositivity of Caspase3 protein in the brain tissue of the MCAO group was significantly higher than that of the control group, and that of the MCAO + miR-29b antagomir group was significantly decreased. The green arrow indicates the positive expression area. (B, C) Flow cytometry detection of the percentage of apoptotic cells in mouse brain tissue. (D) Bands of caspase3 protein expression in mouse brain tissue detected by western blot assay. (E) Quantitative results showing caspase3 protein expression, which was normalized to β-actin. Values are represented as the mean ± SD (n= 6 in each group). *P< 0.05 (Student's t-test). DAPI: 4′,6-Diamidino-2-phenylindole; miR-29b: microRNA-29b.