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. 2021 Aug 17;49(17):9755–9767. doi: 10.1093/nar/gkab706

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Schematic representation of chromatin dynamics mediated by DNA methylation and histone modifications. (A) Euchromatin, with H3K9ac and H3K18ac histone marks and minimal levels of methylated DNA after catalysis by DNA demethylases (in green above right-pointing arrow). (B) Euchromatin, with relatively high levels of methylated DNA (shown as light and dark grey –CH3 groups) catalyzed by DNA methyltransferases (in green below left-pointing arrow), or transitioned from facultative heterochromatin after catalysis by IDM1 and HAG1. (C) Facultative heterochromatin, transitioned from highly methylated euchromatin after catalysis by HDA6, or transitioned from constitutive heterochromatin after IBM1 catalysis. (D) Constitutive heterochromatin, transitioned from facultative heterochromatin after catalysis by SUVH4/5/6.