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. 2021 Aug 14;49(17):10106–10119. doi: 10.1093/nar/gkab707

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Structural and functional analysis of the HD domain. (A) The cavity on the HD domain. The conserved residues in the cavity are colored purple, while other regions are colored white. (B) The aminoacylation activities of wild-type EcGlyRS and its variants with single mutations in the HD domain. (C) The structural superposition between the HD domain and the Mid1 subdomain of Archaeoglobus fulgidus AlaRS (AfAlaRS) in complex with tRNA^Ala (PDB: 3wqy). Mid 1 (cyan) in the tRNA-recognition domain of AfAlaRS and tRNA^Ala(black) are shown as cartoons. The discriminator base A73 and the G3·U70 pair in tRNA^Ala are presented as sticks. The polar contact between Asp459 and U70 is indicated by the yellow dashed line.