Figure 5.

Using YciT as an example to illustrate type II local regulators. (A) An overview of YciT binding profile across E. coli K-12 MG1655 genome. S/N denotes signal-to-noise ratio. (+) and (−) indicate reads mapped on forward and reverse strands, respectively. (B) YciT binding peaks located upstream of operon ybiUVWY and gene fsaA. (C) The binding peak located upstream of gene ybiO. (D) Growth profiles of the wild type and yciT deletion strains in the absence and presence of 0.5 M NaCl in M9 minimal medium with 0.2% (w/v) sorbitol as the sole carbon source. Width of shaded bands represents standard deviation of the corresponding growth trajectory.