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Contributions of the interdomain linker in stabilizing a closed conformation in the presence of ligands. The product state mimic structure of CthTpt1 illustrates the numerous contacts between the N- and C-lobes. The conserved N-terminus of the variable linker 81GHSI84 (the corresponding region in RslTpt1 is 79GHSV82) shown in cyan plays a major role in maintaining inter-lobe contacts some of which are mediated by the ADP-ribose-1″-phosphate and pAp products.
