Table.
Hypertensive disorder rates
| Hypertensive disorder | Negative SARS-CoV-2 (n=1498) | Positive SARS-CoV-2 (n=151) | P value (univariable) | P value (multivariable)a | Odds ratio (95% CI)a | ||
|---|---|---|---|---|---|---|---|
| Overall rate of HDP | 131 (8.7) | 32 (21.2) | <.01 | <.01 | 1.98 (1.26–3.10) | ||
| Gestational hypertension | 56 (3.7) | 16 (10.6) | <.01 | .02 | 2.13 (1.15–3.92) | ||
| Preeclampsia without severe features | 20 (1.3) | 7 (4.6) | <.01 | .02 | 3.02 (1.18–7.71) | ||
| Preeclampsia with severe features | 55 (3.7) | 9 (6.0) | .17 | .65 | 1.19 (0.56–2.51) | ||
| Hypertensive disorder severity | |||||||
|---|---|---|---|---|---|---|---|
| Outcome | Negative SARS-CoV-2 (n=131) | Positive SARS-CoV-2 (n=32) | P value | ||||
| Requirement for rapid acting antihypertensive medications | 33 (25.2) | 4 (12.5) | .12 | ||||
| Preeclamptic laboratory abnormalities | 14 (10.7) | 5 (15.6) | .54 | ||||
| Platelets<100 (× 103/µL) | 3 (2.3) | 1 (3.1) | >.99 | ||||
| AST or ALT>2 times normal (U/L) | 9 (6.9) | 5 (15.6) | .15 | ||||
| Creatinine>1.1 (mg/dL) | 4 (3.0) | 0 (0) | >.99 | ||||
| Preeclamptic symptoms | .27 | ||||||
| Headache | 9 (6.9) | 0 (0) | |||||
| Vision changes | 0 (0) | 1 (3.1) | |||||
| Chest pain | 1 (0.8) | 0 (0) | |||||
| RUQ pain | 1 (0.8) | 0 (0) | |||||
| Pulmonary edema | 1 (0.8) | 0 (0) | |||||
| Magnesium intrapartum | 34 (26.0) | 6 (18.8) | .40 | ||||
| Magnesium postpartum | 55 (42.0) | 9 (28.1) | .15 | ||||
| Requirement for antihypertensive medications after birth | 48 (36.6) | 6 (18.8) | .05 | ||||
| Number of antihypertensive medications after birth | |||||||
| 1 antihypertensive | 42 (32.1) | 6 (18.8) | .14 | ||||
| >1 antihypertensive | 6 (4.6) | 0 (0) | .60 | ||||
| Readmission for preeclampsia | 9 (6.9) | 1 (3.1) | .69 | ||||
Data are presented as number (percentage), unless otherwise indicated.
ALT, alanine transaminase; AST, aspartate transaminase; HDP, hypertensive disorders of pregnancy; RUQ, right upper quadrant.
a
Controlled for maternal age, advance maternal age status, race, and insurance type; observations with unknown insurance status were excluded in the multivariable analysis (n=1329).
Madden. SARS-CoV-2 and hypertensive disease in pregnancy. Am J Obstet Gynecol MFM 2021.