Table 3.
Associations between body composition and breast cancer
| Model 1a OR (95% CI) |
Model 2b aOR (95% CI) |
Model 3c aOR (95% CI) |
Model 4d aOR (95% CI) |
|
|---|---|---|---|---|
| BMI (kg/m2) quartile | ||||
| ≤ 22.5 | Ref. | Ref. | Ref. | Ref. |
| > 22.5 - ≤25.6 | 0.79 (0.52, 1.22) | 0.76 (0.49, 1.18) | 0.73 (0.44, 1.22) | 0.60 (0.31, 1.19) |
| > 25.6 - ≤29.8 | 0.68 (0.44, 1.04) | 0.65 (0.42, 1.01) | 0.63 (0.38, 1.04) | 0.38 (0.15, 0.95) |
| > 29.8 | 0.60 (0.39, 0.92) | 0.56 (0.36, 0.86) | 0.56 (0.33, 0.92) | 0.32 (0.10, 1.09) |
| P-trend | .01 | .01 | .02 | .06 |
| aOR (95% CI) per unit SD | 0.81 (0.70, 0.94) | 0.79 (0.68, 0.93) | 0.79 (0.67, 0.95) | 0.75 (0.15, 3.72) |
| Height (cm) quartile | ||||
| ≤ 156.0 | Ref. | Ref. | Ref. | Ref. |
| > 156.0 - ≤160.0 | 1.05 (0.67, 1.64) | 1.07 (0.68, 1.68) | 1.05 (0.62, 1.76) | 0.90 (0.51, 1.57) |
| > 160.0 - ≤164.0 | 1.41 (0.94, 2.10) | 1.45 (0.97, 2.16) | 1.29 (0.81, 2.05) | 1.12 (0.66, 1.90) |
| > 164.0 | 1.22 (0.81, 1.84) | 1.27 (0.84, 1.91) | 1.08 (0.67, 1.73) | 0.87 (0.48, 1.60) |
| P-trend | .17 | .13 | .55 | .85 |
| aOR (95% CI) per unit SD | 1.15 (0.99, 1.34) | 1.16 (1.00, 1.36) | 1.07 (0.90, 1.28) | 1.05 (0.56, 1.96) |
| Weight (kg) quartile | ||||
| ≤ 56.7 | Ref. | Ref. | Ref. | Ref. |
| > 56.7 - ≤65.0 | 0.85 (0.56, 1.31) | 0.84 (0.54, 1.28) | 0.75 (0.46, 1.24) | 1.09 (0.55, 2.15) |
| > 65.0 - ≤77.0 | 0.89 (0.58, 1.37) | 0.87 (0.56, 1.34) | 0.93 (0.56, 1.57) | 2.04 (0.78, 5.29) |
| > 77.0 | 0.74 (0.48, 1.14) | 0.71 (0.46, 1.10) | 0.63 (0.38, 1.04) | 1.70 (0.48, 5.98) |
| P-trend | .22 | .16 | .14 | .31 |
| aOR (95% CI) per unit SD | 0.86 (0.74, 1.00) | 0.85 (0.73, 0.99) | 0.83 (0.69, 0.98) | 1.06 (0.20, 5.75) |
P-trend based on continuous predictors; aOR per unit SD modeled as a one-unit increase in standard deviation of the variable from its mean-centered value
Bolded values indicate significance at p < .05
Abbreviations: OR odds ratio, CI confidence interval, aOR adjusted odds ratio, SD standard deviation
Logistic regression models predicted odds of breast cancer. aModel 1, unadjusted; bModel 2, adjusted for age; cModel 3, additionally adjusted for clinical and reproductive characteristics: age at menarche, number of pregnancies, number of births, menopausal status, and prior hypertension diagnosis; dModel 4, additionally adjusted for all body composition measures: BMI, height, and weight