Table 3.
Top 10 up- and down-regulated DEcircRNAs between patients with ischemic stroke and normal controls
| GeneID | circBaseID | log2FC | p-value | Regulation | Host gene | N1 | N2 | N3 | P1 | P2 | P3 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| chr4:178,274,461|178,274,882 | hsa_circ_0001459 | 3.037662 | 0 | up | NEIL3 | 0 | 0 | 253 | 1296 | 395 | 725 |
| chr17:53,478,829|53,481,229 | hsa_circ_0002015 | 2.576615 | 0 | up | MMD | 1059 | 108 | 92 | 1819 | 2522 | 4393 |
| chr12:58,340,777|58,347,472 | hsa_circ_0000412 | 2.298732 | 0 | up | ATP23 | 648 | 0 | 391 | 1371 | 2061 | 2513 |
| chr21:37,711,076|37,717,005 | hsa_circ_0001189 | 2.129201 | 0 | up | MORC3 | 130 | 496 | 460 | 1620 | 1052 | 2853 |
| chr9:6,880,011|6,893,232 | hsa_circ_0001839 | 2.1205 | 0 | up | KDM4C | 259 | 237 | 506 | 50 | 2390 | 2627 |
| chr17:20,107,645|20,109,225 | hsa_circ_0000745 | 2.025537 | 0 | up | SPECC1 | 583 | 1444 | 529 | 8198 | 1096 | 2808 |
| chr3:169,840,378|169,847,340 | hsa_circ_0067900 | 3.239944 | 3.03E-277 | up | PHC3 | 151 | 0 | 0 | 1096 | 110 | 453 |
| chr18:196,636|199,316 | hsa_circ_0007706 | 3.034998 | 9.43E-260 | up | USP14 | 130 | 43 | 0 | 648 | 548 | 453 |
| chr1:205,238,077|205,239,012 | hsa_circ_0003344 | 2.098331 | 4.26E-231 | up | TMCC2 | 43 | 172 | 230 | 1047 | 241 | 928 |
| chr1:29,362,337|29,379,824 | hsa_circ_0011173 | 3.928555 | 3.58E-223 | up | EPB41 | 65 | 0 | 0 | 50 | 263 | 838 |
| chr16:11,214,471|11,217,803 | hsa_circ_0037852 | -5.09647 | 0 | down | CLEC16A | 281 | 431 | 759 | 50 | 0 | 0 |
| chr18:45,391,429|45,396,935 | hsa_circ_0003694 | -3.13386 | 0 | down | SMAD2 | 562 | 625 | 1402 | 299 | 44 | 0 |
| chr7:104,925,455|104,937,980 | hsa_circ_0003656 | -2.84711 | 0 | down | SRPK2 | 540 | 970 | 965 | 199 | 88 | 113 |
| chr15:50,330,964|50,339,661 | hsa_circ_0035197 | -2.41562 | 0 | down | ATP8B4 | 1664 | 2478 | 2896 | 797 | 307 | 430 |
| chr20:60,737,807|60,738,678 | hsa_circ_0003231 | -3.34158 | 1.31E-276 | down | SS18L1 | 216 | 388 | 782 | 0 | 0 | 159 |
| chr10:11,312,628|11,330,515 | hsa_circ_0017680 | -2.63557 | 8.20E-247 | down | CELF2 | 1102 | 453 | 0 | 0 | 132 | 159 |
| chr9:126,519,981|126,531,842 | hsa_circ_0088474 | -4.5753 | 1.71E-220 | down | DENND1A | 130 | 151 | 621 | 0 | 44 | 0 |
| chr6:83,667,030|83,754,378 | hsa_circ_0008236 | -3.23452 | 9.18E-219 | down | UBE3D | 346 | 43 | 736 | 50 | 44 | 45 |
| chr19:58,904,342|58,904,854 | hsa_circ_0005598 | -2.15791 | 9.64E-214 | down | RPS5 | 605 | 474 | 621 | 0 | 307 | 136 |
| chr17:20,910,208|20,914,622 | hsa_circ_0042458 | -3.45041 | 2.27E-212 | down | USP22 | 238 | 129 | 667 | 0 | 110 | 0 |
DEcircRNAs differentially expressed circRNAs; FC fold change, N1-3 normal controls; P1-3 patients with ischemic stroke