Table 3. Results of Coagulation and Fibrinolytic parameters.

Normal values-PT (prothrombin time): 11-14 sec; APTT (activated partial thromboplastin time): 24-35 seconds; Fibrinogen: 200-400 mg/dl; D-Dimer: ≤0.5 µg/ml; Protein C:70-130%; Free Protein S:60-140%, Antithrombin:80-120%; tPA (Tissue Plasminogen Activator) 2-12 ng/ml; INR- International normalized ratio

*shows significant p-value

Parameters	Outcome		p-value	SOFA score		p-value	ARDS	Non-ARDS	p-value
	Survivor	Non-survivor		0	≥1
PT                  D0	13.9 ± 7.7	13.8 ± 1.72	0.96	14.58±9.81	13.1±1.4	0.41	13.45±1.45	,14.14±8.8	0.71
D3	13.4 ± 5.99	15.4 ± 2.33	0.37	14.09±7.57	13.25±2.0	0.55	13.59±2.25	13.76±6.8	0.91
D7	13.7±4.4	15.6 ±3.6	0.23	13.8 ±5.79	14.1±2.48	0.81	14.42±2.79	13.69±5.1	0.54
Discharge	13.3±2.77	0	-	14.1± 3.99	12.7± 1.04	0.94	13.1± 1.04	13.44± 3.16	0.49
INR                 D0	0.93 ± 0.2	1.06 ± 0.17	0.09	0.92±0.25	0.98±0.12	0.23	1.01±0.13	0.92±0.22	0.1
D3	1 ± 0.46	1.1 ± 0.17	0.39	1.04±0.59	0.98±0.15	0.54	1±0.17	1±0.53	0.89
D7	1±0.34	1.05±0.39	0.75	1.02±0.45	1.01±0.22	0.96	1±0.25	1±0.39	0.83
Discharge	0.99±0.21	0	-	1.04± 0.3	0.94± 0.08	1.0	0.97±0.07	0.99±0.24	0.44
APTT              D0	27.5 (20,120)	30.7 (26.2,40.6)	0.03*	27.4(21.8,120)	28.4 (20,120)	0.53	29 (20,120)	27.5 (20,120)	0.15
D3	26.7 (20,120)	29.6 (24.9,35.8)	0.14	27.3 (20,120)	25.9 (20,41.8)	0.10	25.9 (20,41.2)	27.4 (20,120)	0.17
D7	28.5 (20,61.6)	33.7 (27.2,41.6)	0.02*	29.1 (20,61.6)	28.5 (20,41.6)	0.83	28.4 (20,41.6)	28.9 (20,61.6)	0.76
Discharge	25.7(20,46)	0	-	25.7 (22.9,46)	25.7 (20± 29.6)	0.56	27.2 (24.4,29.6)	25.3 (20,46)	0.61
D-Dimer         D0	0.5 (0.27,20)	6.3 (1,20)	<0.001*	0.4 (0.27,20)	1.98 (0.27,20)	<0.001*	2.35 (0.3,20)	0.46 (0.27,20)	0.001*
D3	0.54 (.27,20)	7.6 (0.93,20)	<0.001*	0.42 (0.27,20)	2.21 (0.27,20)	0.001*	3.52 (0.27,20)	0.53 (0.27,20)	<0.001*
D7	0.69 (0.2,20)	9.85 (1.34,20)	<0.001*	0.54 (0.3,20)	2.43 (0.3,20)	0.004*	3.6 (0.3,20)	0.55 (0.27,20)	0.002*
Discharge	0.35 (0.27,20)	0	-	0.34(.27,20)	0.35(0.27,9.39)	0.82	0.64 (0.27,1.36)	0.31 (0.27,20)	0.53
Fibrinogen     D0	260 (29,704)	231.5 (37.6,484)	0.47	235.5 (29,704)	286.5 (37.6,697)	0.15	240 (37.6,697)	260 (29,704)	0.81
D3	210 (28.7,701)	276 (142,572)	0.20	210 (32.4,701)	236 (28.7,588)	0.46	232 (28.7,588)	211.5 (32.4,701)	0.74
D7	219 (22.9,389)	219.5 (87,467)	0.49	187 (22.9,370)	223.5 (40,467)	0.10	220 (40,467)	205.5 (22.9,389)	0.50
Discharge	192 (133,479)	0	-	200.5 (137,433)	171 (133,479)	0.88	161 (159,171)	222.5 (133,479)	0.31
Protein C       D0	78.6±33.25	65.8±27.9	0.50	81±37.8	64.94±24.8	0.04*	82.9±39.8	77.2±26.8	0.05
D3	73.6±36.8	65.1±19.6	0.79	77.7±37.9	62.2±30.7	0.04*	80.19±38.99	72±31.4	0.05
D7	73.4±29.6	52.1 ±35.7	0.07	77.3±34.2	60.4±25.7	0.07	66.3±27.17	66.6±36.5	0.23
Discharge	63.15±18	0	-	68.3±16.88	58.7± 19.05	0.28	48.3±8.0	67.6±17.99	0.09
Protein S        D0	64.3±20.8	58.8±9.86	0.53	62±20.4	67.6±18.2	0.21	69.7±18.2	63.69±20.5	0.43
D3	60.3±26.3s	55.6±14.02	0.67	60.45±25.39	67.5±21.88	0.05	66.6±23.6	61.3±23.7	0.05
D7	59.3±25.3	53±20.17	0.74	54.88±27.1	65.1±20.6	0.22	66.2±21.47	54.7±25.7	0.16
Discharge	69±15.89	0	-	69.5± 12.02	68.5± 24.74	-	51±0	75±12.76	-
Antithrombin D0	82.2±26.5	67.5±25.9	0.14	79.9±28.8	80.8±24.7	0.89	79.04±25.74	81.09±27.4	0.77
D3	76.21±25.2	66.37±17.22	0.53	76.8±24.7	73.8±24.0	0.64	72.0±22.3	77.2±25.3	0.43
D7	53.83±23.22	60.71±23.83	0.06	75.3±26.72	66.2±20.17	0.16	63.8±21.5	74.5±24.5	0.12
Discharge	71.46±27.37	0	-	80.1±28.9	64±25.7	0.25	44±5.2	69.7±25.8	0.01*
tPA                  D0	18.2±11.53	17.6±15.9	0.90	16.77±12.14	19.64±12.03	0.34	19.6±11.9	17.3±12.2	0.47
D3	16.95 ±11.3	14.74±13.5	0.61	15.3±11.18	18.27±12	0.30	17.9±12.08	16.07±11.4	0.53
D7	16.27±12.12	23.98±16.6	0.12	16.48±12.8	18.35±13.3	0.60	17.7±12.8	17.2±13.3	0.90
Discharge	13.71±11.56	0	-	10.4±5.76	16±14.4	0.80	21.73±19.3	11.0±7.6	0.40