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. 2021 Sep 21;13:7325–7337. doi: 10.2147/CMAR.S330228

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© 2021 Zhou et al.

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Biogenesis of circRNAs. (A) The pre-mRNA is folded to form an intron lariat, and then the 3’ tail is removed to form ciRNAs. (B) In lariat-driven circularization, RNA lariat is formed by skipping several exons during pre-mRNA splicing. (C) In intron-pairing-driven circularization, ElciRNA or EcircRNA was produced by complementary pairing of intron sequences. (D) In RBP-mediated circularization, RBP connects the upstream and downstream of introns to form the ElciRNAs or EcircRNAs.

Abbreviations: ciRNAs, circular intronic RNAs; ElciRNAs, exon-intronic circRNAs; EcircRNAs, exonic circRNAs; RBP, RNA-binding protein.