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. 2021 Sep 21;13:7299–7309. doi: 10.2147/CMAR.S318378

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© 2021 Guan et al.

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SNHG22 promotes glycolysis and proliferation. (A) Glucose uptake analysis, (B) lactate production analysis, and (C) ATP analysis explored the glucose uptake, lactate production, and ATP accumulation. (D) Extracellular acidification rate (ECAR) analysis tested the glycolytic capacity in ovarian cancer cells transfected with sh-SNHG22 or overexpressed SNHG22. (E) CCK8 assay detected the proliferation of A2780 and ES-2 cells transfected with sh-SNHG22 or overexpressed SNHG22. (F) Flow cytometry assays revealed that SNHG22 affected cell apoptosis (G) Tumor volume and (H) weight were measured in vivo when injected with overexpressed SNHG22 in A2780 cells. (I) CCK8 assay detected the proliferation of ES-2 cells transfected with overexpressed SNHG22 and treated with 2.5mM 2-DG or 100 μM 3-BP. *P < 0.05, **P < 0.01.