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. 2021 Sep 21;13:7299–7309. doi: 10.2147/CMAR.S318378

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© 2021 Guan et al.

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SP1 regulates SNHG22 expression by serving as a transcription activator. (A) The SP1 interference efficiency using 2 different siRNAs and negative control detected by qRT-PCR. (B) qRT-PCR analysis was used to explore SNHG22 expression after SP1 knockdown in A2780 cells. (C) The luciferase activity was measured by transfecting SNHG22 promoter in A2780 cells. (D) SP1 mainly enriched on the promoter (− 900 bp~ − 600 bp) of SNHG22 in A2780 and ES-2 cells. (E) The luciferase activity was measured by transfecting different SNHG22 promoter region in A2780 cells. *P < 0.05, **P < 0.01.