Table 4.
The detailed information on the GO analysis of the upregulated and downregulated DEGs in GSE86300.
| Category | Term | Count | p value |
|---|---|---|---|
| Upregulated | |||
| BP | Signal transduction | 13 | 0.029093438 |
| BP | Oxidation-reduction process | 9 | 0.024404362 |
| BP | Lipid metabolic process | 8 | 0.00998742 |
| BP | Negative regulation of apoptotic process | 8 | 0.028039906 |
| BP | Intracellular signal transduction | 6 | 0.057525068 |
| BP | DNA replication | 5 | 0.003880893 |
| BP | Positive regulation of ERK1 and ERK2 cascade | 5 | 0.01671187 |
| BP | Small GTPase mediated signal transduction | 5 | 0.034683472 |
| BP | Negative regulation of lipoprotein lipase activity | 4 | 2.69E-06 |
| BP | Triglyceride homeostasis | 4 | 3.64E-04 |
| CC | Extracellular exosome | 25 | 0.00346128 |
| CC | Extracellular region | 23 | 5.66E-05 |
| CC | Extracellular space | 18 | 0.00145449 |
| CC | Cytosol | 16 | 0.035864717 |
| CC | Intracellular membrane-bounded organelle | 11 | 0.004880998 |
| CC | Cell surface | 9 | 0.014877768 |
| CC | Blood microparticle | 6 | 5.91E-04 |
| CC | Apical plasma membrane | 6 | 0.026095659 |
| CC | Basolateral plasma membrane | 4 | 0.084936357 |
| CC | Extracellular vesicle | 3 | 0.025790832 |
| MF | Oxidoreductase activity | 8 | 0.048891279 |
| MF | Calcium ion binding | 8 | 0.090469254 |
| MF | Enzyme inhibitor activity | 4 | 0.001278238 |
| MF | Phospholipid binding | 4 | 0.012646826 |
| MF | Heparin binding | 4 | 0.05071775 |
| MF | Heme binding | 4 | 0.072179828 |
| MF | ATPase activity | 4 | 0.098135899 |
| MF | Fatty acid binding | 3 | 0.008936699 |
| MF | Glutathione transferase activity | 3 | 0.014161492 |
| MF | ATPase activity, coupled to transmembrane movement of substances | 3 | 0.029804054 |
| Downregulated | |||
| BP | Lipid metabolic process | 16 | 9.41E-08 |
| BP | Oxidation-reduction process | 15 | 0.0000495 |
| BP | Cell differentiation | 9 | 0.094964371 |
| BP | Spermatogenesis | 6 | 0.096883326 |
| BP | Steroid metabolic process | 5 | 0.001609187 |
| BP | Fatty acid metabolic process | 5 | 0.014290964 |
| BP | Regulation of blood coagulation | 4 | 0.000187 |
| BP | Hippocampus development | 4 | 0.009520707 |
| BP | Protein folding | 4 | 0.041356989 |
| BP | Organic anion transport | 3 | 0.003069172 |
| CC | Membrane | 62 | 3.31E-05 |
| CC | Extracellular region | 22 | 8.29E-04 |
| CC | Endoplasmic reticulum | 14 | 0.037877677 |
| CC | Extracellular space | 14 | 0.085953795 |
| CC | Intracellular membrane-bounded organelle | 13 | 0.001184947 |
| CC | Perinuclear region of cytoplasm | 9 | 0.044162931 |
| CC | Endoplasmic reticulum membrane | 9 | 0.04998487 |
| CC | Cell surface | 8 | 0.068104588 |
| CC | Growth cone | 5 | 0.013026472 |
| CC | Organelle membrane | 4 | 0.016577263 |
| MF | ATP binding | 16 | 0.038783118 |
| MF | Oxidoreductase activity | 14 | 7.50E-05 |
| MF | Calcium ion binding | 9 | 0.06266387 |
| MF | Heme binding | 5 | 0.022041571 |
| MF | Organic anion transmembrane transporter activity | 4 | 3.09E-04 |
| MF | Calcium-dependent protein binding | 4 | 0.00854366 |
| MF | Unfolded protein binding | 4 | 0.010726793 |
| MF | Metallopeptidase activity | 4 | 0.073836747 |
| MF | Sodium-independent organic anion transmembrane transporter activity | 3 | 0.011626112 |
| MF | Heat shock protein binding | 3 | 0.041228079 |
BP: biological process; CC: cellular component; MF: molecular function.