Table 1:
Baseline patient characteristics and treatment details
Characteristic | Patients (n=51) |
---|---|
Median age [IQR] - yr | 64 [59-71] |
Sex - no. (%) | |
Female | 29 (57%) |
Male | 22 (43%) |
Cigarette smoking status - no. (%) | |
Former or current | 43 (84%) |
Never | 8 (16%) |
Histology - no. (%) | |
Adenocarcinoma | 36 (71%) |
Non-adenocarcinoma | 8 (16%) |
Small cell lung cancer | 7 (14%)* |
PD-L1 expression by TPS - no./total no. (%) | |
0% | 11/33 (33%) |
1-49% | 7/33 (21%) |
≥ 50% | 15/33 (45%)* |
Unknown or not applicable | 18 |
Line of therapy - no. (%) | |
1 or early stage | 28 (55%) |
2 | 13 (25%) |
3 or higher | 10 (20%) |
Past medical history - no. (%) | |
Autoimmune condition^ | 7 (14%) |
Prior thoracic radiation therapy | 11 (22%) |
Treatment - no. (%) | |
Anti-PD-(L)1 monotherapy | 25 (49%) |
Anti-PD-(L)1+CTLA-4 combination | 19 (37%) |
Anti-PD-(L)1+chemotherapy | 5 (10%) |
Anti-PD-(L)1+other (non-chemotherapy) | 2 (4%) |
Percentages may not add up to 100 due to rounding
Autoimmune condition including thyroiditis (n=3), inflammatory bowel disease (n=2), psoriasis (n=2), reactive airways disease (n=1), type 2 diabetes (n=1). IQR = interquartile range, PD-(L)1 = programmed cell death protein (ligand) 1, TPS = tumor proportion score, CTLA-4 = cytotoxic T-lymphocyte-associated protein 4