TABLE 3.

Analytical validation of miRNAs. The accuracy of miRNAs was evaluated using ROC curve analysis. Once the cutoff value was selected for each miRNA, according to the sensitivity and specificity, positive and negative predictive values and power were calculated to analyze the performance of our biomarkers

	Vaginal miR-21	Vaginal miR-155	Anal miR-21	Anal miR-155
AUC	0.8426	0.8028	0.8350	0.8416
p	<.0001	.0007	.0007	.0016
Sensitivity (%)	89.36	84.09	83.33	84.62
Specificity (%)	66.67	75.00	82.35	70.59
Positive predictive value	87.50	90.20	75.00	61.00
Negative predictive value	70.6	63.16	76.00	75.00
Power	80.63	80.87	82.26	80.35

Abbreviation: AUC, Area Under Curve.