Table 2.
Univariate and multivariate analysis of different prognostic features in 149 patients with hepatocellular carcinoma
| Variable | Univariate analysis* | Multivariate analysis† | |||
|---|---|---|---|---|---|
| All cases | Mean survival (months) | P value | HR (95% CI) | P value | |
| Age (years) | 0.924 | ||||
| ≤50 | 77 | 75.9 | |||
| >50 | 72 | 76.8 | |||
| Sex | 0.678 | ||||
| Male | 20 | 75.5 | |||
| Female | 129 | 76.0 | |||
| HbsAg | 0.270 | ||||
| Positive | 125 | 77.9 | |||
| Negative | 23 | 69.1 | |||
| AFP (ng/mL) | 0.182 | ||||
| ≤20 | 60 | 80.9 | |||
| >20 | 87 | 74.0 | |||
| Liver cirrhosis | 0.047 | ||||
| Yes | 122 | 73.9 | |||
| No | 27 | 87.0 | |||
| Tumor size (cm) | 0.019 | ||||
| ≤5 | 90 | 80.5 | |||
| >5 | 59 | 65.3 | |||
| Tumor multiplicity | 0.388 | ||||
| Single | 113 | 77.7 | |||
| Multiple | 36 | 72.4 | |||
| Differentiation | 0.146 | ||||
| Well | 98 | 79.5 | |||
| Moderate-Poor | 51 | 70.3 | |||
| Stage | 0.001 | ||||
| I | 74 | 85.0 | |||
| II-III | 75 | 66.9 | |||
| Vascular invasion | <0.0001 | <0.0001 | |||
| Absent | 97 | 84.2 | 1.0 | ||
| Present | 52 | 56.9 | 4.255 (2.073–8.734) | ||
| KIF2C expression | 0.001 | 0.002 | |||
| Low | 67 | 86.6 | 1.0 | ||
| High | 82 | 68.3 | 4.168 (1.712–0.147) | ||
*Log-rank test; †Cox regression model; HR indicates hazards ratio; CI indicates confidence interval.