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. 2021 Sep 25;17(10):91. doi: 10.1007/s11306-021-01841-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — IonFlow analysis of the human ionome data set from HeLa cells. A PCA of the elemental profiles of the knockdown mutants. B The relevance element-element correlation network is shown (Pearson’s correlation, relevance threshold 0.15). C The genetic relevance network between selected high-impact elemental profiles of knockdown mutants is depicted (Mahalanobis cosine similarity, relevance threshold 0.6); nodes are coloured according to network modules found via network community detection. D Impact-betweenness analysis of the knockdown mutants