Fig. 2.

Humanized CD147 transgenic mouse model with SARS-CoV-2 and variants infection mimics COVID-19 pathology. a Schematic diagram of the method to construct hCD147 mice. b Inoculation of hCD147 mice via the intranasal at 3 × 10⁵ TCID₅₀ of SARS-CoV-2, and sample collected at 2, 6, and 13 d.p.i. c Weight changes were monitored (n = 5). d Taqman RT-qPCR for viral RNA levels in the lung, heart, spleen, kidney, and liver (n = 5). e H&E staining of lung tissue sections from infected hCD147 mice (scale bars, 50 μm). f hCD147 mice were inoculated via the intranasal route with 3 × 10⁵ TCID₅₀ of alpha or beta variant, and sample collected at 6 d.p.i. g H&E staining of lung tissue sections from infected hCD147 mice (scale bars, 50 μm)