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. 2021 Sep 25;12(10):877. doi: 10.1038/s41419-021-04152-2

Fig. 2. Pressure overload induces the increased expression and secretion of Wnt5a and Wnt11 from cardiomyocytes and cardiac fibroblasts.

Fig. 2

A The expressions of Wnt5a and Wnt11 were analyzed by western blot in the heart tissues of patients with dilated cardiomyopathy (DCM) or control (Ctrl) group, n = 4/group. B Western blot analysis of Wnt5a and Wnt11 expressions in heart tissues from TAC mice at different time-points (3 days, 1 week, 2 weeks, 4 weeks), n = 5/group. C, D Western blot analysis of Wnt5a and Wnt11 expression in cardiac myocytes (CMs), fibroblasts (CFs), and their supernatants at different time-points (6, 12, 24, 36, and 48 h) after mechanical stretch (MS), n = 6/group. All data were shown as mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001.