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. 2021 Sep 25;12(10):877. doi: 10.1038/s41419-021-04152-2

Fig. 6. Exogenous Wnt5a and Wnt11 activates fibrosis-related signaling in neonatal rat cardiac fibroblasts.

Fig. 6

A The expression of Col-1, MMP9, MMP2, and TGF-β1 were detected by western blot analysis in cardiac fibroblasts stimulated with exogenous recombinant rat Wnt5a (rWnt5a) or Wnt11 (rWnt11) at different concentrations (0, 10, 50, 100 ng/ml) for 24 h. n = 6/group. B The levels of p-EGFR, p-ERK, and p-P38 were examined in cardiac fibroblasts stimulated with exogenous recombinant rat Wnt5a (rWnt5a) or Wnt11 (rWnt11) at different concentrations (0, 10, 50, 100 ng/ml) and different time-points (0, 5, 10, 30 min), n = 6/group. All data were shown as mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001.