Table 3.

Group differences (overweight/obesity > healthy weight) in BOLD response to high-calorie foods > non-food objects in a priori ROIs and at whole-brain cluster level.

a priori ROIs
ROI	Hemisphere	K(E)	x	y	z1	t	Uncorrected p-value2	Peak-level PFWE-corr3	Cohen’s d’
OFC	L	632	−27	38	−19	5.33	<0.001	0.019	1.14
aINS	L	232	−39	20	−1	5.04	<0.001	0.015	0.69
	R	243	42	8	−7	4.58	<0.001	0.036	0.78
Amygdala	R	30	24	2	−16	3.40	0.001	0.092	0.09
Whole-brain cluster level
ROI	Hemisphere	K(E)	x	y	z1	t	Uncorrected p-value4	Peak-level PFWE-corr5	Cohen’s d’
ACC	L	73	−12	29	17	5.17	0.001	0.009	1.47
	R	67	15	29	5	6.64	0.001	0.013	1.69
Striate area/ BA 17	L R	144 131	−6 12	−97 −94	−10 −4	6.09 6.05	<0.001 <0.001	<0.001 <0.001	0.02 0.07
aINS	R	107	39	−1	5	5.51	<0.001	0.001	1.11
OFC	L	175	−21	32	−13	5.42	<0.001	<0.001	1.27
	R	59	18	32	−13	5.50	0.001	0.023	1.50

¹Coordinates are presented in MNI space

²Voxel-wise t-test significance level p<0.05 uncorrected for multiple comparisons within a hypothesized ROI; ROIs listed represent regions of significantly activated clusters within the a priori hypothesized ROI

³FWE rate (family-wise error rate) used for SVC (small volume correction): Peak-level significance level (FWE-corrected within the search volume of interest); p values for ROIs reaching p(FWE-corrected)<0.05 are bolded

⁴Voxel-wise t-test significance level p<0.05 uncorrected

⁵FWE rate (family-wise error rate) used for cluster-level significance level; p values for ROIs reaching p(FWE-corrected)<0.05 are bolded

ACC: anterior cingulate cortex; BA: Brodmann area; aINS: anterior insula; OFC: orbitofrontal cortex