Table 2.
WHO AWaRe Committee on Selection and Use of Essential Medicines15
| Group | Characteristics of antibiotics or antibiotic classes | Antibiotics used for H. pylori eradication |
|---|---|---|
| Access | 1. Activity against a wide range of commonly encountered susceptible pathogens 2. Showing lower resistance potential 3. Should be widely available and affordable 4. Essential first-choice or second-choice empirical treatment options |
amoxicillin, tetracycline, metronidazole, doxycycline, |
| Watch | 1. Higher risk of selection of bacterial resistance 2. The highest priority agents among the critically important antimicrobials for human medicine 3. Should be prioritized as key targets of stewardship programs and monitoring |
clarithromycin, ciprofloxacin, levofloxacin, rifabutin |
| Reserve | 1. Should be reserved for treatment of confirmed or suspected infections due to multi drug-resistant organisms 2. Treated as “last-resort” options 3. Should be tailored to highly specific patients and settings to preserve their effectiveness |
minocycline |
The 2019 WHO AWaRe classification of antibiotics for evaluation and monitoring of use. Geneva: World Health Organization; 2019. (WHO/EMP/IAU/2019.11). License: CCBY-NC-SA3.0IGO 15