Effect of oral administration of CFW on inflammation of the lacrimal gland in PM2.5-induced DED rats. (A) Representative images of H&E staining in the lacrimal gland (n = 6). Yellow arrows indicate neo-vessels. Scale bar, 50 μm. (B) Representative images of immunohistochemical staining for CD4, IL-17, and TNF-α in lacrimal gland sections (n = 5). Scale bar, 50 μm. The brown-stained precipitates indicate the presence of the target antigen. (C) The stained area of the photograph was quantitative analyzed using ImageJ® and calculated in terms of the fold of the control. ** p < 0.01 and *** p < 0.001 compared to the control group. The data are expressed as the means ± standard deviation (n = 3). # p < 0.05, ## p < 0.01 and ### p < 0.001 compared to the PM2.5-induced DED group.