Table 2.
Effect of oral administration of CFW on the hematological, biochemical, and lipid profiles in SD rats after topical exposure to PM2.5.
| Group | ||||||
|---|---|---|---|---|---|---|
| Control | DED | CFW 200 | CFW 400 | Lutein | CsA | |
| RBC (106/μL) | 8.15 ± 0.16 | 8.20 ± 0.12 | 8.11 ± 0.24 | 8.03± 0.35 | 8.06 ± 0.15 | 7.91 ± 0.30 |
| WBC (103/μL) | 5.10 ± 0.73 | 4.55 ± 1.23 | 4.82 ± 0.86 | 4.32 ± 0.98 | 4.41 ± 1.11 | 4.09 ± 1.37 |
| Hematocrit (%) | 50.04 ± 1.65 | 49.58 ± 1.25 | 49.96 ± 2.08 | 49.42 ± 2.65 | 50.56 ± 1.24 | 49.62 ± 2.21 |
| Hemoglobin(g/dL) | 15.46 ± 0.21 | 15.32 ± 0.17 | 15.25 ± 0.82 | 15.08 ± 0.95 | 15.06 ± 0.69 | 15.04 ± 0.51 |
| MCV (fL) | 61.42 ± 1.71 | 60.32 ± 0.97 | 60.87 ± 1.11 | 61.52 ± 1.40 | 61.20 ± 0.82 | 61.20 ± 2.24 |
| MCH (pg) | 19.00 ± 0.32 | 18.72 ± 0.34 | 18.89 ± 0.63 | 18.76 ± 0.62 | 19.04 ± 0.45 | 19.20 ± 0.71 |
| MCHC (g/dL) | 30.98 ± 0.57 | 31.02 ± 0.27 | 30.44 ± 0.61 | 30.50 ± 0.44 | 30.38 ± 0.73 | 30.96 ± 0.47 |
| Platelet (103/μL) | 839.60 ± 81.15 | 912.67 ± 63.07 | 885.71 ± 54.83 | 873.40 ± 62.96 | 870.80 ± 45.92 | 898.00 ± 48.46 |
| AST (U/L) | 141.26 ± 24.35 | 150.88 ± 20.75 | 142.18 ± 19.48 | 138.04 ± 23.77 | 143.28 ± 15.23 | 139.30 ± 21.43 |
| ALT (U/L) | 20.94 ± 2.49 | 22.93 ± 3.68 | 21.53 ± 3.05 | 22.48 ± 4.14 | 21.42 ± 1.57 | 20.54 ± 2.55 |
| ALP (U/L) | 428.24 ± 41.58 | 428.87 ± 63.12 | 431.17 ± 48.49 | 421.12 ± 62.66 | 439.28 ± 38.65 | 428.76 ± 79.26 |
| BUN (mg/dL) | 14.19 ± 0.94 | 14.40 ± 1.15 | 14.38 ± 1.02 | 14.89 ± 0.75 | 14.22 ± 1.66 | 14.43 ± 1.30 |
| Creatinine (mg/dL) | 0.48 ± 0.03 | 0.48 ± 0.04 | 0.48 ± 0.02 | 0.47 ± 0.03 | 0.48 ± 0.02 | 0.48 ± 0.03 |
| TC (mg/dL) | 57.98 ± 3.37 | 74.47 ± 5.95 ** | 66.18 ± 3.35 | 62.20 ± 3.77 # | 65.38 ± 8.59 | 60.65 ± 4.17 # |
| TG (mg/dL) | 48.44 ± 5.13 | 48.00 ± 7.94 | 45.77 ± 5.85 | 43.64 ± 6.62 | 45.26 ± 8.72 | 46.58 ± 8.63 |
| HDL-C (mg/dL) | 29.50 ± 3.26 | 28.35 ± 3.97 | 28.97 ± 3.49 | 29.18 ± 3.32 | 28.56 ± 3.33 | 29.32 ± 4.25 |
| LDL-C (mg/dL) | 6.08 ± 0.39 | 9.68 ± 1.28 *** | 7.78 ± 0.65 # | 7.18 ± 0.91 ## | 8.45 ± 0.21 ** | 8.47 ± 0.90 ** |
| FFA (uEq/L) | 665.00 ± 27.81 | 720.17 ± 82.88 | 688.61 ± 49.04 | 683.60 ± 43.76 | 676.20 ± 102.10 | 695.00 ± 56.31 |
The data are expressed as mean ± standard deviation (n = 5). ** p < 0.01 and *** p < 0.001 compared to the control group. # p < 0.05 and ## p < 0.01 compared to PM2.5-induced DED group. RBC, red blood cell; WBC, white blood cell; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, MCH concentration; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; BUN, blood urea nitrogen; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; FFA, free fatty acid.