Table 3.

Metabolic pathway analysis of metabolite ranking data from PLSDA models comparing CIA vs. CO at each time-point and CIA pair analysis at each time. Data expressed as “% of metabolic pathway impact (p-value)”.

BML	Alanine, Aspartate, and Glutamate Metabolism	Arginine and Proline Metabolism	Ascorbate and Aldarate Metabolism	B Vitamin Complex	Butanoate Metabolism	Glycerophospholipid Metabolism	Glycine, Serine, and Threonine Metabolism	Histidine Metabolism	Lysine Metabolism	Nitrogen Metabolism	Pantothenate and CoA Biosynthesis	Valine, Leucine, and Isoleucine Degradation
CIA pair analysis 0 × 18								22 (0.002)	0 (0.066)
CIA pair analysis 18 × 25		14 (0.040)			3 (0.326)			22 (0.027)
CIA pair analysis 25 × 35	26 (0.070)	28 (p < 0.001)	0 (0.154)		3 (0.337)		3 (0.109)	22 (0.029)		0 (0.154)		33 (0.185)
CIA pair analysis 35 × 45		22 (0.007)			3 (0.337)	11 (0.103)	2 (0.109)	0 (0.244)				33 (0.185
CIA pair analysis 45 × 55	15 (0.074)	21 (0.001)				11 (0.110)	0 (0.453)	22 (0.032)	0 (0.074)	0 (0.159)
CIA pair analysis 55 ×65									0 (0.002)
NMR
CIA pair analysis 0 × 18								22 (0.166)	0 (0.030)
CIA pair analysis 18 × 25								22 (0.130)
CIA pair analysis 25 × 35							0 (0.284)	22 (0.010)	0 (0.023)			2 (0.336)
CIA pair analysis 35 × 45		1 (0.487)				0 (0.364)	0 (0.374)	22 (0.202)			2 (0.202)	2 (0.437)
CIA pair analysis 45 × 55		1 (0.503)				0 (0.378)		22 (0.210)	0 (0.001)		2 (0.021)
CIA pair analysis 55 × 65								61 (0.001)	0 (0.001)		2 (0.184)
CIA vs. CO at 18 days	6 (0.113)				0 (0.104)		0 (0.144)	24 (0.072)	0 (0.020)	0 (0.044)
CIA vs. CO at 25 days	0 (0.113)				0 (0.104)		0 (0.009)					0 (0.053)
CIA vs. CO at 35 days					0 (0.010)		0 (0.199)	22 (0.101)			2 (0.101)	0 (0.075)
CIA vs. CO at 45 days	0 (0.227)	0 (0.378)			0 (0.021)		0 (0.284)	22 (0.148)	0 (0.042)			0 (0.111)
CIA vs. CO at 55 days	0 (0.157)			8 (0.062)	0 (0.145)	4 (0.193)	0 (0.199)	22 (0.101)				0 (0.075)
CIA vs. CO at 65 days							0 (0.144)	22 (0.002)				2 (0.174)