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. 2021 Sep 10;22(18):9804. doi: 10.3390/ijms22189804

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Anticancer therapeutic potential of AMD3100 (Plerixafor). Mozobil® (Plerixafor) was approved in combination with G-CSF to mobilise hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with NHL or MM. In addition, CXCR4 antagonists can disrupt the adhesive interactions between tumor cells and CXCL12-secreting stromal cells, mobilising them from the TME, and making the tumor cells more accessible to cytotoxic drugs. Furthermore, AMD3100 enhances the infiltration of CD8⁺ T cells, reduces immunosuppressive cells and converts Treg to Thelper-like cells in tumors.