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. 2021 Aug 24;9(9):1794. doi: 10.3390/microorganisms9091794

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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SARS-CoV-2s viral protein interactions with host cell structures and processes. (A) SARS-C0V-2 spike (S) protein interacts with host cell receptors ACE2 and TMPRSS2 for cellular entry. (B) Host cell membrane structure proteins interact with SARS-CoV-2 membrane (M) proteins for viral morphogenesis. (C) Host cell lipid processing channels such as ER, Golgi, and ERGIC interact with the SARS-CoV-2 Envelope (E) protein. (D) Host RNA processing components interact with SARS-CoV-2 N, E and Nsp (1,8,9,16), encoded by the SARS-CoV-2 genome. (E) Several structural and non-structural proteins in the SARS-Co-V-2 genome interact with components of the host innate immune system.